Dr. X and the underground syndicate known as Operation: Mindcrime are introduced here.  Headed by X, the Syndicate attacks society by, as both its name and the words of X suggest, giving young men mind control drugs and ordering them to kill political and religious leaders.  The Syndicate uses people who, like Nikki, dislike the status quo, but have no direction in their lives and don't know how to try to change things.  They are ensnared with rhetoric, telling them they can make a difference in the world by killing those who corrupt it.  We gain more insight into Nikki's past.  He was a skinhead, perhaps in a gang, that did drugs.  A true rebel without a cause, exactly what the Syndicate wants.  As such, Nikki falls easily into X's web.
    X makes Nikki feel welcome.  He ensares alienated young men by convincing them that they can be part of something that will make a difference.  He somehow knows things about Nikki (my guess is that this song details an "application interview" of sorts), which makes him more convincing.  Nikki's plea at the end of the song represents his desire to bring about change; the jumbled voices represent the society whose attention he's trying to get.